The 22nd Maine Regiment was mustered in for nine months' service on October 18, 1862 and were mustered out on August 14, 1863. Re-enlisted men and recruits reorganized as the 14th Battalion Maine Infantry. Of the men enrolled in the regiment, 9 were killed or died of wounds and 160 died of disease.
They served in the following engagements:
- Franklin, LA - April 15, 1863
- Port Hudson, LA - May 27 - July 9, 1863
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